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Application de la chimie de la prodrogue à base de peptides dans le développement de médicaments par Arnab De (
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- Achat immédiatApplication de la chimie de la prodrogue à base de peptides dans le développement de médicaments par Arnab De (
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Numéro de l'objet eBay :395163429563
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Caractéristiques de l'objet
- État
- ISBN-13
- 9781461448747
- Book Title
- Application of Peptide-Based Prodrug Chemistry in Drug Developmen
- ISBN
- 9781461448747
- Subject Area
- Science, Medical
- Publication Name
- Application of Peptide-Based Prodrug Chemistry in Drug Development
- Item Length
- 9.3 in
- Publisher
- Springer New York
- Subject
- Chemistry / Clinical, Pharmacy, Pharmacology, Chemistry / Organic
- Series
- Springerbriefs in Pharmaceutical Science and Drug Development Ser.
- Publication Year
- 2012
- Type
- Textbook
- Format
- Trade Paperback
- Language
- English
- Item Width
- 6.1 in
- Item Weight
- 6.1 Oz
- Number of Pages
- Xii, 89 Pages
À propos de ce produit
Product Information
Macromolecular (specifically peptide-based) drugs could potentially be highly effective medicines. However they have a relatively short duration of action and variable therapeutic index. An example of such a peptide is Glucagon-like Peptide I which could potentially be used as a revolutionary drug for diabetes. This is because it stimulates insulin only when the blood glucose level is high thereby reducing the risk of hypoglycemia (a significant disadvantage of using insulin is that an insulin overdose is the single most potent cause of life-threatening hypoglycemia). However it's short duration of action (half-life of 2 minutes in plasma) precludes its therapeutic use. In this volume, the use of novel therapeutics like GLP1 as an alternative to tradition insulin-based drugs in diabetes is described. Application of Peptide-Based Prodrug Chemistry in Drug Development elucidates the traditional concept of prodrugs as "specialized non-toxic protective groups used in a transient manner to alter or to eliminate certain limiting properties in the parent small molecule" (IUPAC definition). It goes on to provide insight into how prodrugs of peptides (with GLP1 as an example) could be appropriately used to extend the biological half life, broaden the therapeutic index of macromolecules and improve the pharmacodynamics of such drugs. Author explains the logic behind designing peptide prodrugs, synthetic procedures and bioassays to examine the conversion of the prodrug to the drug under therapeutic conditions. The prodrugs described slowly convert to the parent drug at physiological conditions of 37C and pH 7.2 driven by their inherent chemical instability without the need of any enzymatic cleavage. The diketopiperazine and diketomorpholine (DKP and DMP) strategies for prodrug conversion are demonstrated in detail with special emphasis on the chemical flexibility that it offers to develop prodrugs with variable time actions. This book will be of usefulto chemists, biochemists, medicinal chemists, biologists and people in the medical profession (doctors). It may be used in undergraduate classes but will certainly help post-graduate students and advanced professionals. The author is grateful to Prof. Richard DiMarchi (Standiford H. Cox Professor of Chemistry and the Linda & Jack Gill Chair in Biomolecular Sciences at Indiana University) for valuable suggestions. The foreword for the book has been written by Prof. Jean Martinez, (Legion d'Honneur awarded by the French Republic; Professor of Chemistry and Medicinal Chemistry of the University of Montpellier, France; and Chairman of European Peptide Society, 2002-2010).
Product Identifiers
Publisher
Springer New York
ISBN-10
1461448743
ISBN-13
9781461448747
eBay Product ID (ePID)
117284722
Product Key Features
Publication Name
Application of Peptide-Based Prodrug Chemistry in Drug Development
Format
Trade Paperback
Language
English
Subject
Chemistry / Clinical, Pharmacy, Pharmacology, Chemistry / Organic
Series
Springerbriefs in Pharmaceutical Science and Drug Development Ser.
Publication Year
2012
Type
Textbook
Subject Area
Science, Medical
Number of Pages
Xii, 89 Pages
Dimensions
Item Length
9.3 in
Item Width
6.1 in
Item Weight
6.1 Oz
Additional Product Features
Intended Audience
Scholarly & Professional
Number of Volumes
1 Vol.
Lc Classification Number
Rs400-431
Table of Content
Macromolecular (specifically peptide-based) drugs could potentially be highly effective medicines. However they have a relatively short duration of action and variable therapeutic index. An example of such a peptide is Glucagon-like Peptide I which could potentially be used as a revolutionary drug for diabetes. This is because it stimulates insulin only when the blood glucose level is high thereby reducing the risk of hypoglycemia (a significant disadvantage of using insulin is that an insulin overdose is the single most potent cause of life-threatening hypoglycemia). However it's short duration of action (half-life of 2 minutes in plasma) precludes its therapeutic use. In this volume, the use of novel therapeutics like GLP1 as an alternative to tradition insulin-based drugs in diabetes is described. Application of Peptide-Based Prodrug Chemistry in Drug Development elucidates the traditional concept of prodrugs as "specialized non-toxic protective groups used in a transient manner to alter or to eliminate certain limiting properties in the parent small molecule" (IUPAC definition). It goes on to provide insight into how prodrugs of peptides (with GLP1 as an example) could be appropriately used to extend the biological half life, broaden the therapeutic index of macromolecules and improve the pharmacodynamics of such drugs. Author explains the logic behind designing peptide prodrugs, synthetic procedures and bioassays to examine the conversion of the prodrug to the drug under therapeutic conditions. The prodrugs described slowly convert to the parent drug at physiological conditions of 37C and pH 7.2 driven by their inherent chemical instability without the need of any enzymatic cleavage. The diketopiperazine and diketomorpholine (DKP and DMP) strategies for prodrug conversion are demonstrated in detail with special emphasis on the chemical flexibility that it offers to develop prodrugs with variable time actions. This book will be of usefulto chemists, biochemists, medicinal chemists, biologists and people in the medical profession (doctors). It may be used in undergraduate classes but will certainly help post-graduate students and advanced professionals. The author is grateful to Prof. Richard DiMarchi (Standiford H. Cox Professor of Chemistry and the Linda & Jack Gill Chair in Biomolecular Sciences at Indiana University) for valuable suggestions. The foreword for the book has been written by Prof. Jean Martinez, (Legion d'Honneur awarded by the French Republic; Professor of Chemistry and Medicinal Chemistry of the University of Montpellier, France; and Chairman of European Peptide Society, 2002-2010). Table of contents: Introduction.- Aapplication of Prodrug Chemistry to GLP-1.- Experimental procedures.- Characterization of Prodrugs.- Conclusion.
Copyright Date
2013
Illustrated
Yes
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Informations sur le vendeur professionnel
Premier Books LLC
David Taylor
26C Trolley Sq
19806-3356 Wilmington, DE
United States
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Numéro de l'objet eBay :395163429563
Dernière mise à jour le 19 mai 2024 14:17:16 CEST. Afficher toutes les modificationsAfficher toutes les modifications
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